Microscopy and chemical imaging

A picture says more than a thousand spectra. That is why we combine vibrational spectroscopy with optical microscopy and develop new imaging techniques to generate high-resolution molecular-specific images of biomedical samples. These chemical images provide valuable insights into the molecular mechanisms of diseases and help in the accurate diagnosis of pathologies and the evaluation of therapy efficacy.

Raman spectroscopy is a non-invasive, non-contact, label-free quantitative method that can be used in physiological, aqueous environments and is therefore excellently suited for biomedical applications. We are developing new parallelised techniques for rapid chemical imaging of biomedical processes from a subcellular to a macroscopic scale.

Using these microspectroscopic methods, we can obtain molecular information with sub-μm spatial resolution. This allows for early and accurate disease diagnosis in cells (e.g. malaria infection) and for the efficient monitoring of inter- and intracellular processes (e.g. drug-induced changes).

Publications

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